LIMK2
Entrez ID: 3985
Full name: LIM domain kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: LISK: LIMK
Chromosomal location: 22q12.2
Substructure location: Gatekeeper: 405 A-loop: 468...511 G-loop: [N/A] αC-helix: 367...375
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LIMK2
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and ...
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403).
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GO - Biological processes (BP):
actin cytoskeleton organization, astral microtubule organization, cornea development in camera-type eye, head development, phosphorylation, protein phosphorylation, spermatogenesis...
actin cytoskeleton organization, astral microtubule organization, cornea development in camera-type eye, head development, phosphorylation, protein phosphorylation, spermatogenesis
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
mitotic spindle, cis-Golgi network, nucleus, cytoplasm...
mitotic spindle, cis-Golgi network, nucleus, cytoplasm
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LIM domain kinase 2
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Kaplan plot for LIMK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc