MAPK10
Entrez ID: 5602
Full name: mitogen-activated protein kinase 10
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: JNK
Chromosomal location: 4q21.3
Substructure location: Gatekeeper: 146 A-loop: 206...216, 220...228 G-loop: 67...79 αC-helix: 98...100
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MAPK10
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JN...
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296).
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GO - Biological processes (BP):
cellular hyperosmotic response, Fc-epsilon receptor signaling pathway, intracellular signal transduction, JNK cascade, negative regulation of transcription by RNA polymerase II, neurotransmitter receptor transport to postsynaptic membrane, protein phosphorylation, regulation of circadian rhythm, reg...
cellular hyperosmotic response, Fc-epsilon receptor signaling pathway, intracellular signal transduction, JNK cascade, negative regulation of transcription by RNA polymerase II, neurotransmitter receptor transport to postsynaptic membrane, protein phosphorylation, regulation of circadian rhythm, regulation of DNA-binding transcription factor activity, regulation of gene expression, response to light stimulus, response to water deprivation, rhythmic process, signal transduction, vesicle-mediated transport in synapse
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GO - Molecular function (MF):
ATP binding, JUN kinase activity, MAP kinase activity, MAP kinase kinase activity...
ATP binding, JUN kinase activity, MAP kinase activity, MAP kinase kinase activity
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GO - Cellular component (CC):
cytosol, mitochondrion, nucleoplasm, nucleus, plasma membrane, cytoplasm, glutamatergic synapse, neuron projection, perikaryon...
cytosol, mitochondrion, nucleoplasm, nucleus, plasma membrane, cytoplasm, glutamatergic synapse, neuron projection, perikaryon
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mitogen-activated protein kinase 10
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*NOTE: the Kaplan plots were collected from OncoLnc