EPHA5
Entrez ID: 2044
Full name: EPH receptor A5
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 4q13.1-q13.2
Substructure location: Gatekeeper: 753 A-loop: 817...843 G-loop: 681...687 αC-helix: 715...728
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EPHA5
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pa...
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
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GO - Biological processes (BP):
axon guidance, cAMP-mediated signaling, ephrin receptor signaling pathway, hippocampus development, multicellular organism development, neuron development, positive regulation of CREB transcription factor activity, positive regulation of kinase activity, regulation of actin cytoskeleton organization...
axon guidance, cAMP-mediated signaling, ephrin receptor signaling pathway, hippocampus development, multicellular organism development, neuron development, positive regulation of CREB transcription factor activity, positive regulation of kinase activity, regulation of actin cytoskeleton organization, regulation of GTPase activity, regulation of insulin secretion involved in cellular response to glucose stimulus, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, ephrin receptor activity, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, ephrin receptor activity, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
rough endoplasmic reticulum, external side of plasma membrane, integral component of plasma membrane, plasma membrane, axon, dendrite, neuron projection, neuronal cell body, perinuclear region of cytoplasm, receptor complex...
rough endoplasmic reticulum, external side of plasma membrane, integral component of plasma membrane, plasma membrane, axon, dendrite, neuron projection, neuronal cell body, perinuclear region of cytoplasm, receptor complex
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EPH receptor A5
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Kaplan plot for EPHA5 in
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*NOTE: the Kaplan plots were collected from OncoLnc