EPHB4
Entrez ID: 2050
Full name: EPH receptor B4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 7q22.1
Substructure location: Gatekeeper: 693 A-loop: 757...785 G-loop: 621...627 αC-helix: 655...668
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EPHB4
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling p...
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
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GO - Biological processes (BP):
angiogenesis, cell adhesion, cell migration involved in sprouting angiogenesis, ephrin receptor signaling pathway, heart morphogenesis, multicellular organism development, positive regulation of kinase activity, protein autophosphorylation, transmembrane receptor protein tyrosine kinase signaling pa...
angiogenesis, cell adhesion, cell migration involved in sprouting angiogenesis, ephrin receptor signaling pathway, heart morphogenesis, multicellular organism development, positive regulation of kinase activity, protein autophosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, extracellular region, integral component of plasma membrane, plasma membrane, receptor complex...
cytosol, extracellular exosome, extracellular region, integral component of plasma membrane, plasma membrane, receptor complex
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EPH receptor B4
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Kaplan plot for EPHB4 in
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*NOTE: the Kaplan plots were collected from OncoLnc