EPHB1
Entrez ID: 2047
Full name: EPH receptor B1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 3q22.2
Substructure location: Gatekeeper: 697 A-loop: 761...789 G-loop: 624...635 αC-helix: 659...672
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EPHB1
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling p...
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).
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GO - Biological processes (BP):
angiogenesis, axon guidance, camera-type eye morphogenesis, cell chemotaxis, cell-substrate adhesion, central nervous system projection neuron axonogenesis, dendritic spine development, dendritic spine morphogenesis, detection of temperature stimulus involved in sensory perception of pain, ephrin re...
angiogenesis, axon guidance, camera-type eye morphogenesis, cell chemotaxis, cell-substrate adhesion, central nervous system projection neuron axonogenesis, dendritic spine development, dendritic spine morphogenesis, detection of temperature stimulus involved in sensory perception of pain, ephrin receptor signaling pathway, establishment of cell polarity, immunological synapse formation, modulation of chemical synaptic transmission, multicellular organism development, negative regulation of satellite cell differentiation, negative regulation of skeletal muscle satellite cell proliferation, neural precursor cell proliferation, neurogenesis, optic nerve morphogenesis, positive regulation of kinase activity, positive regulation of synapse assembly, protein autophosphorylation, regulation of ERK1 and ERK2 cascade, regulation of JNK cascade, regulation of neuron death, retinal ganglion cell axon guidance, skeletal muscle satellite cell activation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, axon guidance receptor activity, protein-containing complex binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, axon guidance receptor activity, protein-containing complex binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum, early endosome membrane, extracellular exosome, extracellular region, integral component of plasma membrane, plasma membrane, axon, dendrite, filopodium tip, glutamatergic synapse, membrane raft, receptor complex...
cytosol, endoplasmic reticulum, early endosome membrane, extracellular exosome, extracellular region, integral component of plasma membrane, plasma membrane, axon, dendrite, filopodium tip, glutamatergic synapse, membrane raft, receptor complex
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EPH receptor B1
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Kaplan plot for EPHB1 in
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*NOTE: the Kaplan plots were collected from OncoLnc