CSNK2A1
Entrez ID: 1457
Full name: casein kinase 2 alpha 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: CK2
Chromosomal location: 20p13
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 75...88
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CSNK2A1
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, ...
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).
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GO - Biological processes (BP):
apoptotic process, cell cycle, chaperone-mediated protein folding, macroautophagy, negative regulation of apoptotic signaling pathway, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of ubiquitin-dependent protein catabolic process, pept...
apoptotic process, cell cycle, chaperone-mediated protein folding, macroautophagy, negative regulation of apoptotic signaling pathway, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of ubiquitin-dependent protein catabolic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, phosphatidylcholine biosynthetic process, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of protein catabolic process, positive regulation of Wnt signaling pathway, protein folding, protein phosphorylation, regulation of cell cycle, regulation of chromosome separation, regulation of signal transduction by p53 class mediator, rhythmic process, signal transduction, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, Hsp90 protein binding, identical protein binding, kinase activity, protein N-terminus binding, protein serine/threonine kinase activity...
ATP binding, Hsp90 protein binding, identical protein binding, kinase activity, protein N-terminus binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, NuRD complex, Sin3 complex, plasma membrane, protein kinase CK2 complex...
cytosol, nucleoplasm, nucleus, NuRD complex, Sin3 complex, plasma membrane, protein kinase CK2 complex
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casein kinase 2 alpha 1
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Kaplan plot for CSNK2A1 in
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*NOTE: the Kaplan plots were collected from OncoLnc