SRPK2
Entrez ID: 6733
Full name: SRSF protein kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: SRPK
Chromosomal location: 7q22.3
Substructure location: Gatekeeper: 166 A-loop: [N/A] G-loop: [N/A] αC-helix: 116...134
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SRPK2
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal ...
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
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GO - Biological processes (BP):
angiogenesis, cell differentiation, innate immune response, intracellular signal transduction, negative regulation of viral genome replication, nuclear speck organization, peptidyl-serine phosphorylation, positive regulation of cell cycle, positive regulation of cell population proliferation, positi...
angiogenesis, cell differentiation, innate immune response, intracellular signal transduction, negative regulation of viral genome replication, nuclear speck organization, peptidyl-serine phosphorylation, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of viral genome replication, protein phosphorylation, regulation of gene expression, regulation of mRNA processing, regulation of mRNA splicing, via spliceosome, RNA splicing, spliceosomal complex assembly
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GO - Molecular function (MF):
14-3-3 protein binding, ATP binding, magnesium ion binding, protein serine/threonine kinase activity, RNA binding...
14-3-3 protein binding, ATP binding, magnesium ion binding, protein serine/threonine kinase activity, RNA binding
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GO - Cellular component (CC):
cytosol, nucleolus, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleolus, nucleoplasm, nucleus, cytoplasm
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SRSF protein kinase 2
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Kaplan plot for SRPK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc