CSNK1G2
Entrez ID: 1455
Full name: casein kinase 1 gamma 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: CK1: CK1-G
Chromosomal location: 19p13.3
Substructure location: Gatekeeper: 119 A-loop: 187...217 G-loop: 49...62 αC-helix: 86...95
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CSNK1G2
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brai...
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
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GO - Biological processes (BP):
peptidyl-serine phosphorylation, positive regulation of canonical Wnt signaling pathway, protein autophosphorylation, protein phosphorylation, signal transduction, sphingolipid biosynthetic process, Wnt signaling pathway...
peptidyl-serine phosphorylation, positive regulation of canonical Wnt signaling pathway, protein autophosphorylation, protein phosphorylation, signal transduction, sphingolipid biosynthetic process, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, plasma membrane, cytoplasm, membrane...
cytosol, nucleus, plasma membrane, cytoplasm, membrane
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casein kinase 1 gamma 2
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*NOTE: the Kaplan plots were collected from OncoLnc