MAP3K9
Entrez ID: 4293
Full name: mitogen-activated protein kinase kinase kinase 9
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: MLK
Chromosomal location: 14q24.2
Substructure location: Gatekeeper: 220 A-loop: 293...314 G-loop: 151...158 αC-helix: 185...197
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MAP3K9
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade thr...
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
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GO - Biological processes (BP):
activation of JUN kinase activity, apoptotic process, positive regulation of apoptotic process, protein autophosphorylation, protein phosphorylation...
activation of JUN kinase activity, apoptotic process, positive regulation of apoptotic process, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase activity, protein homodimerization activity, protein serine/threonine kinase activity...
ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase activity, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
-...
-
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mitogen-activated protein kinase kinase kinase 9
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Kaplan plot for MAP3K9 in
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*NOTE: the Kaplan plots were collected from OncoLnc