CDK3
Entrez ID: 1018
Full name: cyclin dependent kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK1
Chromosomal location: 17q25.1
Substructure location: Gatekeeper: 80 A-loop: 144...167 G-loop: [N/A] αC-helix: [N/A]
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CDK3
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivat...
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
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GO - Biological processes (BP):
cell division, cell population proliferation, cellular response to DNA damage stimulus, G0 to G1 transition, G1/S transition of mitotic cell cycle, protein phosphorylation...
cell division, cell population proliferation, cellular response to DNA damage stimulus, G0 to G1 transition, G1/S transition of mitotic cell cycle, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, cyclin-dependent protein serine/threonine kinase activity...
ATP binding, cyclin-dependent protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus...
nucleus
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cyclin dependent kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc