CDK16
Entrez ID: 5127
Full name: cyclin dependent kinase 16
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: PCTAIRE
Chromosomal location: Xp11.3
Substructure location: Gatekeeper: 240 A-loop: 303...326 G-loop: 171...177 αC-helix: 206...217
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CDK16
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarit...
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
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GO - Biological processes (BP):
exocytosis, growth hormone secretion, neuron projection development, protein phosphorylation, regulation of insulin secretion involved in cellular response to glucose stimulus, spermatogenesis...
exocytosis, growth hormone secretion, neuron projection development, protein phosphorylation, regulation of insulin secretion involved in cellular response to glucose stimulus, spermatogenesis
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GO - Molecular function (MF):
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein serine/threonine kinase activity...
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
microtubule cytoskeleton, cytosol, nucleus, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, cell junction, cytoplasm, neuron projection, synaptic vesicle...
microtubule cytoskeleton, cytosol, nucleus, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, cell junction, cytoplasm, neuron projection, synaptic vesicle
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cyclin dependent kinase 16
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*NOTE: the Kaplan plots were collected from OncoLnc