ROR1
Entrez ID: 4919
Full name: receptor tyrosine kinase like orphan receptor 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Ror
Chromosomal location: 1p31.3
Substructure location: Gatekeeper: 552 A-loop: 632...657 G-loop: [N/A] αC-helix: [N/A]
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ROR1
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, ...
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
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GO - Biological processes (BP):
anatomical structure development, astrocyte development, inner ear development, multicellular organism development, nervous system development, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation...
anatomical structure development, astrocyte development, inner ear development, multicellular organism development, nervous system development, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of NF-kappaB transcription factor activity, positive regulation of phosphatidylinositol 3-kinase signaling, regulation of MAPK cascade, sensory perception of sound, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, transmembrane receptor protein tyrosine kinase activity, Wnt-activated receptor activity, Wnt-protein binding...
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, transmembrane receptor protein tyrosine kinase activity, Wnt-activated receptor activity, Wnt-protein binding
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GO - Cellular component (CC):
stress fiber, integral component of plasma membrane, plasma membrane, axon, axon terminus, cell surface, cytoplasm, receptor complex...
stress fiber, integral component of plasma membrane, plasma membrane, axon, axon terminus, cell surface, cytoplasm, receptor complex
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receptor tyrosine kinase like orphan receptor 1
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Kaplan plot for ROR1 in
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*NOTE: the Kaplan plots were collected from OncoLnc