ROR2
Entrez ID: 4920
Full name: receptor tyrosine kinase like orphan receptor 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Ror
Chromosomal location: 9q22.31
Substructure location: Gatekeeper: 553 A-loop: 632...657 G-loop: [N/A] αC-helix: 518...530
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ROR2
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has als...
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).
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GO - Biological processes (BP):
anatomical structure development, astrocyte development, BMP signaling pathway, bone mineralization, cartilage condensation, cell fate commitment, embryonic digit morphogenesis, embryonic genitalia morphogenesis, inner ear morphogenesis, JNK cascade, macrophage migration, male genitalia development,...
anatomical structure development, astrocyte development, BMP signaling pathway, bone mineralization, cartilage condensation, cell fate commitment, embryonic digit morphogenesis, embryonic genitalia morphogenesis, inner ear morphogenesis, JNK cascade, macrophage migration, male genitalia development, multicellular organism development, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, nervous system development, positive regulation of canonical Wnt signaling pathway, positive regulation of cell migration, positive regulation of JUN kinase activity, positive regulation of kinase activity, positive regulation of macrophage differentiation, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein kinase C activity, positive regulation of synaptic transmission, glutamatergic, positive regulation of transcription, DNA-templated, regulation of MAPK cascade, signal transduction, SMAD protein signal transduction, smoothened signaling pathway, somitogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, Wnt signaling pathway, calcium modulating pathway, Wnt signaling pathway, planar cell polarity pathway
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GO - Molecular function (MF):
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, frizzled binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, transmembrane receptor protein tyrosine kinase activity, Wnt-protein binding...
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, frizzled binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, transmembrane receptor protein tyrosine kinase activity, Wnt-protein binding
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GO - Cellular component (CC):
microtubule, integral component of plasma membrane, plasma membrane, axon, cell surface, clathrin-coated endocytic vesicle membrane, dendrite, neuronal cell body, receptor complex...
microtubule, integral component of plasma membrane, plasma membrane, axon, cell surface, clathrin-coated endocytic vesicle membrane, dendrite, neuronal cell body, receptor complex
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receptor tyrosine kinase like orphan receptor 2
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Kaplan plot for ROR2 in
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*NOTE: the Kaplan plots were collected from OncoLnc