MAP2K1
Entrez ID: 5604
Full name: mitogen-activated protein kinase kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK1
Chromosomal location: 15q22.31
Substructure location: Gatekeeper: 143 A-loop: 207...228 G-loop: 74...83 αC-helix: 105...115
Please click HERE
for better display.
MAP2K1
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further acti...
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
View more >>
GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, Bergmann glial cell differentiation, cell cycle arrest, cell motility, cellular senescence, cerebellar cortex formation, chemotaxis, epithelial cell proliferation involved in lung morphogenesis, ERK1 and ERK2 cascade, face developme...
activation of MAPK activity, activation of protein kinase activity, Bergmann glial cell differentiation, cell cycle arrest, cell motility, cellular senescence, cerebellar cortex formation, chemotaxis, epithelial cell proliferation involved in lung morphogenesis, ERK1 and ERK2 cascade, face development, heart development, keratinocyte differentiation, labyrinthine layer development, MAPK cascade, negative regulation of cell population proliferation, negative regulation of gene expression, neuron differentiation, peptidyl-threonine phosphorylation, placenta blood vessel development, positive regulation of axonogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of protein serine/threonine kinase activity, positive regulation of transcription, DNA-templated, protein phosphorylation, regulation of axon regeneration, regulation of early endosome to late endosome transport, regulation of Golgi inheritance, regulation of mitotic cell cycle, regulation of stress-activated MAPK cascade, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade, thymus development, thyroid gland development, trachea formation
View more >>
GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, MAP-kinase scaffold activity, protein C-terminus binding, protein kinase activity, protein N-terminus binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, pro...
ATP binding, MAP kinase kinase activity, MAP-kinase scaffold activity, protein C-terminus binding, protein kinase activity, protein N-terminus binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold protein binding
View more >>
GO - Cellular component (CC):
microtubule organizing center, cytosol, endoplasmic reticulum, early endosome, late endosome, Golgi apparatus, mitochondrion, nucleus, plasma membrane, cytoplasm, focal adhesion...
microtubule organizing center, cytosol, endoplasmic reticulum, early endosome, late endosome, Golgi apparatus, mitochondrion, nucleus, plasma membrane, cytoplasm, focal adhesion
View more >>
mitogen-activated protein kinase kinase 1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MAP2K1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc