GUCY2D
Entrez ID: 3000
Full name: guanylate cyclase 2D, retinal
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: RGC: RGC
Chromosomal location: 17p13.1
Substructure location: Gatekeeper: 619 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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GUCY2D
Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21928830, PubMed:30319355, PubMed:26100624, PubMed:9600905, PubMed:15123990). May also participate in the trafficking of membrane-as...
Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21928830, PubMed:30319355, PubMed:26100624, PubMed:9600905, PubMed:15123990). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
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GO - Biological processes (BP):
cGMP biosynthetic process, intracellular signal transduction, receptor guanylyl cyclase signaling pathway, regulation of rhodopsin mediated signaling pathway, signal transduction, visual perception...
cGMP biosynthetic process, intracellular signal transduction, receptor guanylyl cyclase signaling pathway, regulation of rhodopsin mediated signaling pathway, signal transduction, visual perception
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GO - Molecular function (MF):
ATP binding, GTP binding, guanylate cyclase activity, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein homodimerization activity, protein kinase activity, signaling receptor activity...
ATP binding, GTP binding, guanylate cyclase activity, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein homodimerization activity, protein kinase activity, signaling receptor activity
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GO - Cellular component (CC):
endoplasmic reticulum membrane, nuclear outer membrane, integral component of plasma membrane, photoreceptor outer segment membrane, plasma membrane, photoreceptor disc membrane, photoreceptor outer segment...
endoplasmic reticulum membrane, nuclear outer membrane, integral component of plasma membrane, photoreceptor outer segment membrane, plasma membrane, photoreceptor disc membrane, photoreceptor outer segment
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guanylate cyclase 2D, retinal
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Kaplan plot for GUCY2D in
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*NOTE: the Kaplan plots were collected from OncoLnc