ACVR1
Entrez ID: 90
Full name: activin A receptor type 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR1
Chromosomal location: 2q24.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 214...220 αC-helix: 239...241
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ACVR1
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be inv...
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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GO - Biological processes (BP):
activin receptor signaling pathway, acute inflammatory response, angiogenesis, atrial septum primum morphogenesis, atrioventricular valve morphogenesis, BMP signaling pathway, BMP signaling pathway involved in heart development, branching involved in blood vessel morphogenesis, cardiac muscle cell f...
activin receptor signaling pathway, acute inflammatory response, angiogenesis, atrial septum primum morphogenesis, atrioventricular valve morphogenesis, BMP signaling pathway, BMP signaling pathway involved in heart development, branching involved in blood vessel morphogenesis, cardiac muscle cell fate commitment, cellular response to BMP stimulus, cellular response to growth factor stimulus, determination of left/right symmetry, embryonic heart tube morphogenesis, endocardial cushion cell fate commitment, endocardial cushion fusion, endocardial cushion morphogenesis, G1/S transition of mitotic cell cycle, gastrulation with mouth forming second, germ cell development, heart development, in utero embryonic development, mesoderm formation, mitral valve morphogenesis, negative regulation of activin receptor signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of signal transduction, neural crest cell migration, pathway-restricted SMAD protein phosphorylation, peptidyl-threonine phosphorylation, pharyngeal system development, positive regulation of bone mineralization, positive regulation of cell migration, positive regulation of determination of dorsal identity, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of osteoblast differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of ossification, smooth muscle cell differentiation, transforming growth factor beta receptor signaling pathway, ventricular septum morphogenesis
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GO - Molecular function (MF):
activin binding, activin receptor activity, type I, ATP binding, cadherin binding, metal ion binding, peptide hormone binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase binding, SMAD binding, transforming growth fact...
activin binding, activin receptor activity, type I, ATP binding, cadherin binding, metal ion binding, peptide hormone binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase binding, SMAD binding, transforming growth factor beta binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity
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GO - Cellular component (CC):
activin receptor complex, BMP receptor complex, integral component of plasma membrane, plasma membrane, apical part of cell, receptor complex...
activin receptor complex, BMP receptor complex, integral component of plasma membrane, plasma membrane, apical part of cell, receptor complex
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activin A receptor type 1
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Kaplan plot for ACVR1 in
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*NOTE: the Kaplan plots were collected from OncoLnc