MST1R
Entrez ID: 4486
Full name: macrophage stimulating 1 receptor
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Met
Chromosomal location: 3p21.31
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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MST1R
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its int...
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
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GO - Biological processes (BP):
defense response, hepatocyte growth factor receptor signaling pathway, innate immune response, multicellular organism development, positive regulation of cell population proliferation, positive regulation of kinase activity, positive regulation of MAP kinase activity, positive regulation of protein ...
defense response, hepatocyte growth factor receptor signaling pathway, innate immune response, multicellular organism development, positive regulation of cell population proliferation, positive regulation of kinase activity, positive regulation of MAP kinase activity, positive regulation of protein kinase B signaling, response to virus, signal transduction, single fertilization, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, enzyme binding, macrophage colony-stimulating factor receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, enzyme binding, macrophage colony-stimulating factor receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
stress fiber, basal plasma membrane, integral component of plasma membrane, plasma membrane, cell surface, receptor complex, vacuole...
stress fiber, basal plasma membrane, integral component of plasma membrane, plasma membrane, cell surface, receptor complex, vacuole
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macrophage stimulating 1 receptor
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Kaplan plot for MST1R in
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*NOTE: the Kaplan plots were collected from OncoLnc