TYRO3
Entrez ID: 7301
Full name: TYRO3 protein tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Axl
Chromosomal location: 15q15.1
Substructure location: Gatekeeper: 603 A-loop: 672...697 G-loop: [N/A] αC-helix: [N/A]
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TYRO3
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerizat...
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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GO - Biological processes (BP):
apoptotic cell clearance, cell adhesion, cell migration, forebrain cell migration, multicellular organism development, natural killer cell differentiation, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of lymphocyte activation, negat...
apoptotic cell clearance, cell adhesion, cell migration, forebrain cell migration, multicellular organism development, natural killer cell differentiation, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of lymphocyte activation, negative regulation of neuron apoptotic process, negative regulation of toll-like receptor signaling pathway, nervous system development, neuron cellular homeostasis, neuropeptide signaling pathway, ovulation cycle, phagocytosis, phosphatidylinositol 3-kinase signaling, platelet activation, platelet aggregation, positive regulation of kinase activity, protein autophosphorylation, protein kinase B signaling, secretion by cell, signal transduction, spermatogenesis, substrate adhesion-dependent cell spreading, transmembrane receptor protein tyrosine kinase signaling pathway, vagina development
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GO - Molecular function (MF):
ATP binding, phosphatidylinositol 3-kinase binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity...
ATP binding, phosphatidylinositol 3-kinase binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity
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GO - Cellular component (CC):
endoplasmic reticulum membrane, nuclear envelope, nucleus, integral component of plasma membrane, cell, cell surface, receptor complex...
endoplasmic reticulum membrane, nuclear envelope, nucleus, integral component of plasma membrane, cell, cell surface, receptor complex
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TYRO3 protein tyrosine kinase
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Kaplan plot for TYRO3 in
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*NOTE: the Kaplan plots were collected from OncoLnc