TNK2
Entrez ID: 10188
Full name: tyrosine kinase non receptor 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Ack
Chromosomal location: 3q29
Substructure location: Gatekeeper: 205 A-loop: 269...279, 281...295 G-loop: 131...142 αC-helix: 171...181
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TNK2
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in traffic...
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).
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GO - Biological processes (BP):
cell differentiation, cell surface receptor signaling pathway, endocytosis, peptidyl-tyrosine autophosphorylation, phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of cell population proliferation, regulation of clathrin-dependent endocytosis, small GTPase mediat...
cell differentiation, cell surface receptor signaling pathway, endocytosis, peptidyl-tyrosine autophosphorylation, phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of cell population proliferation, regulation of clathrin-dependent endocytosis, small GTPase mediated signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, epidermal growth factor receptor binding, GTPase inhibitor activity, identical protein binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase...
ATP binding, epidermal growth factor receptor binding, GTPase inhibitor activity, identical protein binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, signaling receptor binding, ubiquitin protein ligase binding, WW domain binding
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GO - Cellular component (CC):
endosome, nucleus, extrinsic component of cytoplasmic side of plasma membrane, Grb2-EGFR complex, plasma membrane, adherens junction, clathrin-coated pit, clathrin-coated vesicle, cytoophidium, cytoplasm, cytoplasmic vesicle membrane, membrane, perinuclear region of cytoplasm...
endosome, nucleus, extrinsic component of cytoplasmic side of plasma membrane, Grb2-EGFR complex, plasma membrane, adherens junction, clathrin-coated pit, clathrin-coated vesicle, cytoophidium, cytoplasm, cytoplasmic vesicle membrane, membrane, perinuclear region of cytoplasm
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tyrosine kinase non receptor 2
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*NOTE: the Kaplan plots were collected from OncoLnc