ITK
Entrez ID: 3702
Full name: IL2 inducible T cell kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Tec
Chromosomal location: 5q33.3
Substructure location: Gatekeeper: 435 A-loop: 499...523 G-loop: 369...375 αC-helix: 400...411
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ITK
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation l...
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity).
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GO - Biological processes (BP):
activation of phospholipase C activity, adaptive immune response, B cell receptor signaling pathway, cellular defense response, cytokine production, Fc-epsilon receptor signaling pathway, gamma-delta T cell activation, interferon-gamma production, interleukin-4 production, intracellular signal trans...
activation of phospholipase C activity, adaptive immune response, B cell receptor signaling pathway, cellular defense response, cytokine production, Fc-epsilon receptor signaling pathway, gamma-delta T cell activation, interferon-gamma production, interleukin-4 production, intracellular signal transduction, NK T cell differentiation, peptidyl-tyrosine autophosphorylation, signal transduction, T cell activation, T cell receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity...
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, cell-cell junction...
cytosol, nucleus, cell-cell junction
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IL2 inducible T cell kinase
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Kaplan plot for ITK in
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*NOTE: the Kaplan plots were collected from OncoLnc