DMPK
Entrez ID: 1760
Full name: DM1 protein kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: DMPK: GEK
Chromosomal location: 19q13.32
Substructure location: Gatekeeper: 148 A-loop: 212...222, 225...236 G-loop: [N/A] αC-helix: 104...110
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DMPK
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphoryla...
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
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GO - Biological processes (BP):
cellular calcium ion homeostasis, intracellular signal transduction, muscle cell apoptotic process, nuclear envelope organization, peptidyl-serine phosphorylation, protein phosphorylation, regulation of cardiac conduction, regulation of excitatory postsynaptic membrane potential involved in skeletal...
cellular calcium ion homeostasis, intracellular signal transduction, muscle cell apoptotic process, nuclear envelope organization, peptidyl-serine phosphorylation, protein phosphorylation, regulation of cardiac conduction, regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction, regulation of heart contraction, regulation of myotube differentiation, regulation of skeletal muscle contraction by calcium ion signaling, regulation of sodium ion transport, regulation of synapse structural plasticity
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GO - Molecular function (MF):
ATP binding, metal ion binding, myosin phosphatase regulator activity, protein serine/threonine kinase activity...
ATP binding, metal ion binding, myosin phosphatase regulator activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum membrane, sarcoplasmic reticulum membrane, integral component of mitochondrial outer membrane, nuclear membrane, nuclear outer membrane, plasma membrane, cell...
cytosol, endoplasmic reticulum membrane, sarcoplasmic reticulum membrane, integral component of mitochondrial outer membrane, nuclear membrane, nuclear outer membrane, plasma membrane, cell
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DM1 protein kinase
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Kaplan plot for DMPK in
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*NOTE: the Kaplan plots were collected from OncoLnc