MAP4K2
Entrez ID: 5871
Full name: mitogen-activated protein kinase kinase kinase kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: KHS
Chromosomal location: 11q13.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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MAP4K2
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser exte...
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of protein kinase activity, immune response, innate immune response, intracellular signal transduction, JNK cascade, MAPK cascade, positive regulation of JNK cascade, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by prote...
activation of JUN kinase activity, activation of protein kinase activity, immune response, innate immune response, intracellular signal transduction, JNK cascade, MAPK cascade, positive regulation of JNK cascade, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade, vesicle targeting
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase kinase activity, mitogen-activated protein kinase kinase kinase binding, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase kinase kinase activity, mitogen-activated protein kinase kinase kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
Golgi membrane, basolateral plasma membrane, cell, cytoplasm...
Golgi membrane, basolateral plasma membrane, cell, cytoplasm
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mitogen-activated protein kinase kinase kinase kinase 2
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Kaplan plot for MAP4K2 in
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*NOTE: the Kaplan plots were collected from OncoLnc