MAP3K12
Entrez ID: 7786
Full name: mitogen-activated protein kinase kinase kinase 12
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: LZK
Chromosomal location: 12q13.13
Substructure location: Gatekeeper: 190 A-loop: 253...275 G-loop: 132...139 αC-helix: 157...160
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MAP3K12
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway....
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.
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GO - Biological processes (BP):
activation of JNKK activity, activation of JUN kinase activity, histone phosphorylation, intracellular signal transduction, JNK cascade, negative regulation of motor neuron apoptotic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of ERK1 and ERK2 ca...
activation of JNKK activity, activation of JUN kinase activity, histone phosphorylation, intracellular signal transduction, JNK cascade, negative regulation of motor neuron apoptotic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of ERK1 and ERK2 cascade, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, JUN kinase kinase kinase activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, JUN kinase kinase kinase activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, plasma membrane, cytoplasm, growth cone, membrane...
cytosol, plasma membrane, cytoplasm, growth cone, membrane
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mitogen-activated protein kinase kinase kinase 12
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*NOTE: the Kaplan plots were collected from OncoLnc