MERTK
Entrez ID: 10461
Full name: MER proto-oncogene, tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Axl
Chromosomal location: 2q13
Substructure location: Gatekeeper: 671 A-loop: 740...765 G-loop: 592...603 αC-helix: 628...642
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MERTK
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (effer...
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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GO - Biological processes (BP):
apoptotic cell clearance, cell-cell signaling, cell migration, cell surface receptor signaling pathway, leukocyte migration, multicellular organism development, natural killer cell differentiation, negative regulation of cytokine production, negative regulation of leukocyte apoptotic process, negati...
apoptotic cell clearance, cell-cell signaling, cell migration, cell surface receptor signaling pathway, leukocyte migration, multicellular organism development, natural killer cell differentiation, negative regulation of cytokine production, negative regulation of leukocyte apoptotic process, negative regulation of lymphocyte activation, nervous system development, neutrophil clearance, phagocytosis, platelet activation, positive regulation of kinase activity, positive regulation of phagocytosis, protein kinase B signaling, protein phosphorylation, retina development in camera-type eye, secretion by cell, spermatogenesis, substrate adhesion-dependent cell spreading, transmembrane receptor protein tyrosine kinase signaling pathway, vagina development
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GO - Molecular function (MF):
ATP binding, transmembrane receptor protein tyrosine kinase activity...
ATP binding, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
extracellular space, integral component of plasma membrane, plasma membrane, cytoplasm, photoreceptor outer segment, receptor complex, rhabdomere...
extracellular space, integral component of plasma membrane, plasma membrane, cytoplasm, photoreceptor outer segment, receptor complex, rhabdomere
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MER proto-oncogene, tyrosine kinase
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Kaplan plot for MERTK in
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*NOTE: the Kaplan plots were collected from OncoLnc