ABR
Entrez ID: 29
Full name: ABR activator of RhoGEF and GTPase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: BCR
Chromosomal location: 17p13.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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ABR
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to dow...
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity).
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GO - Biological processes (BP):
actin cytoskeleton organization, activation of GTPase activity, brain development, G protein-coupled receptor signaling pathway, inner ear morphogenesis, modulation of chemical synaptic transmission, negative regulation of blood vessel remodeling, negative regulation of cellular extravasation, negat...
actin cytoskeleton organization, activation of GTPase activity, brain development, G protein-coupled receptor signaling pathway, inner ear morphogenesis, modulation of chemical synaptic transmission, negative regulation of blood vessel remodeling, negative regulation of cellular extravasation, negative regulation of inflammatory response, negative regulation of neutrophil degranulation, neuromuscular process controlling balance, positive regulation of apoptotic process, positive regulation of phagocytosis, regulation of small GTPase mediated signal transduction, regulation of vascular permeability, response to lipopolysaccharide, small GTPase mediated signal transduction
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GO - Molecular function (MF):
GTPase activator activity, guanyl-nucleotide exchange factor activity...
GTPase activator activity, guanyl-nucleotide exchange factor activity
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GO - Cellular component (CC):
cytosol, plasma membrane, axon, cell junction, dendritic spine, glutamatergic synapse, membrane, postsynaptic density, intracellular component, Schaffer collateral - CA1 synapse...
cytosol, plasma membrane, axon, cell junction, dendritic spine, glutamatergic synapse, membrane, postsynaptic density, intracellular component, Schaffer collateral - CA1 synapse
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ABR activator of RhoGEF and GTPase
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Gatekeeper
A-loop
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αC-helix
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A-loop
G-loop
αC-helix
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Kaplan plot for ABR in
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*NOTE: the Kaplan plots were collected from OncoLnc