STK4
Entrez ID: 6789
Full name: serine/threonine kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: MST
Chromosomal location: 20q13.12
Substructure location: Gatekeeper: 102 A-loop: 166...178, 180...189 G-loop: 33...45 αC-helix: 68...78
Please click HERE
for better display.
STK4
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restr...
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
View more >>
GO - Biological processes (BP):
activation of protein kinase activity, apoptotic process, branching involved in blood vessel morphogenesis, cell differentiation involved in embryonic placenta development, cell morphogenesis, central nervous system development, endocardium development, hepatocyte apoptotic process, hippo signaling,...
activation of protein kinase activity, apoptotic process, branching involved in blood vessel morphogenesis, cell differentiation involved in embryonic placenta development, cell morphogenesis, central nervous system development, endocardium development, hepatocyte apoptotic process, hippo signaling, intracellular signal transduction, keratinocyte differentiation, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of organ growth, neural tube formation, neuron projection morphogenesis, peptidyl-serine phosphorylation, positive regulation of apoptotic process, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of fat cell differentiation, positive regulation of peptidyl-serine phosphorylation, positive regulation of protein binding, positive regulation of protein phosphorylation, positive regulation of substrate-dependent cell migration, cell attachment to substrate, positive regulation of vascular associated smooth muscle cell apoptotic process, primitive hemopoiesis, protein autophosphorylation, protein phosphorylation, protein stabilization, regulation of cell differentiation involved in embryonic placenta development, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
View more >>
GO - Molecular function (MF):
ATP binding, identical protein binding, magnesium ion binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, transcription factor binding...
ATP binding, identical protein binding, magnesium ion binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, transcription factor binding
View more >>
GO - Cellular component (CC):
cytosol, nuclear body, nucleoplasm, nucleus, cytoplasm, protein-containing complex...
cytosol, nuclear body, nucleoplasm, nucleus, cytoplasm, protein-containing complex
View more >>
serine/threonine kinase 4
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for STK4 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc