MAP2K5
Entrez ID: 5607
Full name: mitogen-activated protein kinase kinase 5
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK5
Chromosomal location: 15q23
Substructure location: Gatekeeper: 241 A-loop: 300...321 G-loop: [N/A] αC-helix: [N/A]
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MAP2K5
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis....
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
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GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, cellular response to growth factor stimulus, cellular response to laminar fluid shear stress, ERK5 cascade, heart development, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of chemokin...
activation of MAPK activity, activation of protein kinase activity, cellular response to growth factor stimulus, cellular response to laminar fluid shear stress, ERK5 cascade, heart development, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of heterotypic cell-cell adhesion, negative regulation of interleukin-8 biosynthetic process, negative regulation of NF-kappaB transcription factor activity, negative regulation of response to cytokine stimulus, negative regulation of transcription by RNA polymerase II, positive regulation of cell growth, positive regulation of epithelial cell proliferation, positive regulation of protein metabolic process, positive regulation of transcription by RNA polymerase II, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, MAP kinase kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
spindle, cytosol, nucleus, cytoplasm...
spindle, cytosol, nucleus, cytoplasm
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mitogen-activated protein kinase kinase 5
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Kaplan plot for MAP2K5 in
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*NOTE: the Kaplan plots were collected from OncoLnc