MAPK7
Entrez ID: 5598
Full name: mitogen-activated protein kinase 7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: ERK5
Chromosomal location: 17p11.2
Substructure location: Gatekeeper: 137 A-loop: 199...226 G-loop: 62...69 αC-helix: 93...108
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MAPK7
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a...
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
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GO - Biological processes (BP):
axon guidance, cAMP-mediated signaling, cell cycle, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to laminar fluid shear stress, cellular response to transforming growth factor beta stimulus, intracellular signal transduction, negative regulat...
axon guidance, cAMP-mediated signaling, cell cycle, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to laminar fluid shear stress, cellular response to transforming growth factor beta stimulus, intracellular signal transduction, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of cyclic-nucleotide phosphodiesterase activity, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of heterotypic cell-cell adhesion, negative regulation of inflammatory response, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of response to cytokine stimulus, peptidyl-serine phosphorylation, positive regulation of protein metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter in response to stress, regulation of angiogenesis, regulation of gene expression, signal transduction
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GO - Molecular function (MF):
ATP binding, MAP kinase activity, mitogen-activated protein kinase binding...
ATP binding, MAP kinase activity, mitogen-activated protein kinase binding
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, PML body, cytoplasm...
cytosol, nucleoplasm, nucleus, PML body, cytoplasm
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mitogen-activated protein kinase 7
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*NOTE: the Kaplan plots were collected from OncoLnc