PAK2
Entrez ID: 5062
Full name: p21 (RAC1) activated kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: PAKA
Chromosomal location: 3q29
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PAK2
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CD...
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
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GO - Biological processes (BP):
activation of protein kinase activity, adherens junction assembly, apoptotic process, bicellular tight junction assembly, cellular response to organic cyclic compound, dendritic spine development, Fc-epsilon receptor signaling pathway, interleukin-12-mediated signaling pathway, negative regulation o...
activation of protein kinase activity, adherens junction assembly, apoptotic process, bicellular tight junction assembly, cellular response to organic cyclic compound, dendritic spine development, Fc-epsilon receptor signaling pathway, interleukin-12-mediated signaling pathway, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis, negative regulation of protein kinase activity, negative regulation of stress fiber assembly, peptidyl-serine phosphorylation, phosphorylation, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, protein autophosphorylation, protein localization to cell-cell junction, protein phosphorylation, regulation of cytoskeleton organization, regulation of defense response to virus by virus, regulation of growth, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stimulatory C-type lectin receptor signaling pathway, stress-activated protein kinase signaling cascade, T cell costimulation, T cell receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, cadherin binding, identical protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activator activity, Rac GTPase binding, small GTPase binding...
ATP binding, cadherin binding, identical protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activator activity, Rac GTPase binding, small GTPase binding
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GO - Cellular component (CC):
cytosol, nucleus, plasma membrane, cell-cell junction, cytoplasm, glutamatergic synapse, perinuclear region of cytoplasm, postsynaptic density...
cytosol, nucleus, plasma membrane, cell-cell junction, cytoplasm, glutamatergic synapse, perinuclear region of cytoplasm, postsynaptic density
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p21 (RAC1) activated kinase 2
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Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
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Kaplan plot for PAK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc