STK3
Entrez ID: 6788
Full name: serine/threonine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: MST
Chromosomal location: 8q22.2
Substructure location: Gatekeeper: 99 A-loop: 163...175, 177...186 G-loop: 32...42 αC-helix: 64...76
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STK3
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restr...
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
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GO - Biological processes (BP):
activation of protein kinase activity, apoptotic process, cell differentiation involved in embryonic placenta development, central nervous system development, endocardium development, hepatocyte apoptotic process, hippo signaling, intracellular signal transduction, negative regulation of canonical W...
activation of protein kinase activity, apoptotic process, cell differentiation involved in embryonic placenta development, central nervous system development, endocardium development, hepatocyte apoptotic process, hippo signaling, intracellular signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of organ growth, neural tube formation, neuron projection morphogenesis, positive regulation of apoptotic process, positive regulation of DNA-binding transcription factor activity, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of fat cell differentiation, positive regulation of JNK cascade, positive regulation of protein binding, positive regulation of protein kinase B signaling, primitive hemopoiesis, protein phosphorylation, protein stabilization, regulation of cell differentiation involved in embryonic placenta development, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, identical protein binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity...
ATP binding, identical protein binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, cytoplasm, protein-containing complex...
cytosol, nucleus, cytoplasm, protein-containing complex
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serine/threonine kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc