NME3
Entrez ID: 4832
Full name: NME/NM23 nucleoside diphosphate kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NDK
Chromosomal location: 16p13.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NME3
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiatio...
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
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GO - Biological processes (BP):
apoptotic process, CTP biosynthetic process, GTP biosynthetic process, nucleobase-containing small molecule interconversion, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, UTP biosynthetic process...
apoptotic process, CTP biosynthetic process, GTP biosynthetic process, nucleobase-containing small molecule interconversion, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, UTP biosynthetic process
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GO - Molecular function (MF):
ATP binding, metal ion binding, nucleoside diphosphate kinase activity...
ATP binding, metal ion binding, nucleoside diphosphate kinase activity
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GO - Cellular component (CC):
cytosol...
cytosol
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NME/NM23 nucleoside diphosphate kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc