PRKG2
Entrez ID: 5593
Full name: protein kinase cGMP-dependent 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKG
Chromosomal location: 4q21.21
Substructure location: Gatekeeper: 530 A-loop: 593...603, 607...615 G-loop: [N/A] αC-helix: [N/A]
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PRKG2
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma...
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
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GO - Biological processes (BP):
cofactor metabolic process, negative regulation of chloride transport, peptidyl-serine autophosphorylation, protein localization to plasma membrane, protein phosphorylation, signal transduction...
cofactor metabolic process, negative regulation of chloride transport, peptidyl-serine autophosphorylation, protein localization to plasma membrane, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, cGMP binding, cGMP-dependent protein kinase activity, identical protein binding, protein kinase activity...
ATP binding, cGMP binding, cGMP-dependent protein kinase activity, identical protein binding, protein kinase activity
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GO - Cellular component (CC):
cytosol, nuclear membrane, apical plasma membrane...
cytosol, nuclear membrane, apical plasma membrane
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protein kinase cGMP-dependent 2
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*NOTE: the Kaplan plots were collected from OncoLnc