ILK
Entrez ID: 3611
Full name: integrin linked kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: ILK
Chromosomal location: 11p15.4
Substructure location: Gatekeeper: 269 A-loop: [N/A] G-loop: [N/A] αC-helix: 229...238
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ILK
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin...
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).
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GO - Biological processes (BP):
branching involved in ureteric bud morphogenesis, cell aging, cell cycle arrest, cell junction assembly, cell-matrix adhesion, establishment or maintenance of epithelial cell apical/basal polarity, fibroblast migration, integrin-mediated signaling pathway, myelin assembly, myelination in peripheral ...
branching involved in ureteric bud morphogenesis, cell aging, cell cycle arrest, cell junction assembly, cell-matrix adhesion, establishment or maintenance of epithelial cell apical/basal polarity, fibroblast migration, integrin-mediated signaling pathway, myelin assembly, myelination in peripheral nervous system, negative regulation of cardiac muscle cell apoptotic process, negative regulation of neural precursor cell proliferation, negative regulation of neuron apoptotic process, negative regulation of protein kinase activity, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, nerve development, neuron projection morphogenesis, outflow tract morphogenesis, peptidyl-serine phosphorylation, platelet aggregation, positive regulation of axon extension, positive regulation of BMP signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cell-matrix adhesion, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of dendrite morphogenesis, positive regulation of MAP kinase activity, positive regulation of myoblast differentiation, positive regulation of NIK/NF-kappaB signaling, positive regulation of osteoblast differentiation, positive regulation of phosphorylation, positive regulation of protein kinase B signaling, positive regulation of protein phosphorylation, positive regulation of signal transduction, positive regulation of transcription, DNA-templated, protein kinase B signaling, protein phosphorylation, regulation of actin cytoskeleton organization, substrate adhesion-dependent cell spreading, supramolecular fiber organization, tumor necrosis factor-mediated signaling pathway
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GO - Molecular function (MF):
ATP binding, integrin binding, protein kinase binding, protein serine/threonine kinase activity, SH3 domain binding...
ATP binding, integrin binding, protein kinase binding, protein serine/threonine kinase activity, SH3 domain binding
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GO - Cellular component (CC):
stress fiber, cytosol, nucleoplasm, plasma membrane, cell junction, cell-cell junction, costamere, dendritic shaft, focal adhesion, lamellipodium, membrane, neuronal cell body, protein-containing complex, sarcomere, terminal bouton...
stress fiber, cytosol, nucleoplasm, plasma membrane, cell junction, cell-cell junction, costamere, dendritic shaft, focal adhesion, lamellipodium, membrane, neuronal cell body, protein-containing complex, sarcomere, terminal bouton
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integrin linked kinase
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Kaplan plot for ILK in
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*NOTE: the Kaplan plots were collected from OncoLnc