ROCK1
Entrez ID: 6093
Full name: Rho associated coiled-coil containing protein kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: DMPK: ROCK
Chromosomal location: 18q11.1
Substructure location: Gatekeeper: 153 A-loop: 215...239 G-loop: 82...88 αC-helix: 109...114
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ROCK1
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskel...
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579, PubMed:23093407, PubMed:23355470). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity).
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GO - Biological processes (BP):
actin cytoskeleton organization, actomyosin structure organization, aortic valve morphogenesis, apical constriction, apoptotic process, bleb assembly, cortical actin cytoskeleton organization, embryonic morphogenesis, ephrin receptor signaling pathway, G protein-coupled receptor signaling pathway, I...
actin cytoskeleton organization, actomyosin structure organization, aortic valve morphogenesis, apical constriction, apoptotic process, bleb assembly, cortical actin cytoskeleton organization, embryonic morphogenesis, ephrin receptor signaling pathway, G protein-coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, leukocyte cell-cell adhesion, leukocyte migration, leukocyte tethering or rolling, membrane to membrane docking, mitotic cytokinesis, mRNA destabilization, myoblast migration, negative regulation of amyloid-beta formation, negative regulation of amyloid precursor protein catabolic process, negative regulation of angiogenesis, negative regulation of bicellular tight junction assembly, negative regulation of biomineral tissue development, negative regulation of membrane protein ectodomain proteolysis, negative regulation of myosin-light-chain-phosphatase activity, negative regulation of neuron apoptotic process, negative regulation of protein binding, neuron projection arborization, neuron projection development, neutrophil degranulation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of amyloid-beta clearance, positive regulation of autophagy, positive regulation of cardiac muscle hypertrophy, positive regulation of connective tissue replacement, positive regulation of focal adhesion assembly, positive regulation of gene expression, positive regulation of MAPK cascade, protein localization to plasma membrane, protein phosphorylation, regulation of actin cytoskeleton organization, regulation of amyloid-beta formation, regulation of angiotensin-activated signaling pathway, regulation of autophagy, regulation of blood vessel diameter, regulation of cell adhesion, regulation of cell junction assembly, regulation of cell migration, regulation of cell motility, regulation of establishment of cell polarity, regulation of establishment of endothelial barrier, regulation of focal adhesion assembly, regulation of keratinocyte differentiation, regulation of microtubule cytoskeleton organization, regulation of neuron differentiation, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, response to angiotensin, response to transforming growth factor beta, Rho protein signal transduction, signal transduction, smooth muscle contraction, vascular endothelial growth factor receptor signaling pathway
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GO - Molecular function (MF):
aspartic-type endopeptidase inhibitor activity, ATP binding, GTP-Rho binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, Rho-dependent protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
aspartic-type endopeptidase inhibitor activity, ATP binding, GTP-Rho binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, Rho-dependent protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
centriole, cytoskeleton, cytosol, extracellular region, Golgi membrane, plasma membrane, bleb, cytoplasm, cytoplasmic stress granule, lamellipodium, ruffle, secretory granule lumen...
centriole, cytoskeleton, cytosol, extracellular region, Golgi membrane, plasma membrane, bleb, cytoplasm, cytoplasmic stress granule, lamellipodium, ruffle, secretory granule lumen
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Rho associated coiled-coil containing protein kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc