TNK1
Entrez ID: 8711
Full name: tyrosine kinase non receptor 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Ack
Chromosomal location: 17p13.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TNK1
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system...
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
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GO - Biological processes (BP):
cell differentiation, negative regulation of cell growth, negative regulation of Ras protein signal transduction, peptidyl-tyrosine autophosphorylation, protein autophosphorylation, protein phosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase s...
cell differentiation, negative regulation of cell growth, negative regulation of Ras protein signal transduction, peptidyl-tyrosine autophosphorylation, protein autophosphorylation, protein phosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
cytosol, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm, membrane...
cytosol, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm, membrane
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tyrosine kinase non receptor 1
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Kaplan plot for TNK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc