ATR
Entrez ID: 545
Full name: ATR serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PIKK: ATR
Chromosomal location: 3q23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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ATR
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, M...
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
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GO - Biological processes (BP):
cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to UV, DNA damage checkpoint, DNA repair, DNA replication, establishment of protein-containing complex localization to telomere, establishment of RNA localization to telomere, interstrand cross-link rep...
cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to UV, DNA damage checkpoint, DNA repair, DNA replication, establishment of protein-containing complex localization to telomere, establishment of RNA localization to telomere, interstrand cross-link repair, multicellular organism development, negative regulation of DNA replication, peptidyl-serine phosphorylation, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of telomerase catalytic core complex assembly, positive regulation of telomere maintenance via telomerase, protein autophosphorylation, protein localization to chromosome, telomeric region, regulation of cellular response to heat, regulation of signal transduction by p53 class mediator, replicative senescence, response to drug, telomere maintenance
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GO - Molecular function (MF):
ATP binding, DNA binding, MutLalpha complex binding, MutSalpha complex binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, DNA binding, MutLalpha complex binding, MutSalpha complex binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
Golgi apparatus, nucleoplasm, nucleus, PML body, chromosome...
Golgi apparatus, nucleoplasm, nucleus, PML body, chromosome
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ATR serine/threonine kinase
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Kaplan plot for ATR in
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*NOTE: the Kaplan plots were collected from OncoLnc