RIPK1
Entrez ID: 8737
Full name: receptor interacting serine/threonine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RIPK
Chromosomal location: 6p25.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 54...56
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RIPK1
Serine-threonine kinase which is a key regulator of both cell death and cell survival (PubMed:25459879). Exhibits kinase activity-dependent functions that trigger cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:2545987...
Serine-threonine kinase which is a key regulator of both cell death and cell survival (PubMed:25459879). Exhibits kinase activity-dependent functions that trigger cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:25459879). Initiates ripoptocide which describes cell death that is dependent on RIPK1, be it apoptosis or necroptosis (PubMed:31457011). Upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kB pathway (By similarity). Specific conditions can however activate RIPK1, and its kinase activity then regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8) and the complex IIb (RIPK1-RIPK3-MLKL) and these complexes respectively drive apoptosis or necroptosis, a regulated form of necrosis (PubMed:19524513, PubMed:19524512, PubMed:29440439, PubMed:30988283). During embryonic development suppresses apoptosis and necroptosis and prevents the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). Phosphorylates DAB2IP at 'Ser-728' in a TNF- alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Required for ZBP1-induced NF-kappaB activation and activation of NF-kappaB by DNA damage and IR (By similarity).
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GO - Biological processes (BP):
activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of JUN kinase activity, amyloid fibril formation, apoptotic process, apoptotic signaling pathway, cell death, cellular protein catabolic process, cellular response to growth factor stimulus, cellular respons...
activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of JUN kinase activity, amyloid fibril formation, apoptotic process, apoptotic signaling pathway, cell death, cellular protein catabolic process, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to tumor necrosis factor, death-inducing signaling complex assembly, extrinsic apoptotic signaling pathway, I-kappaB kinase/NF-kappaB signaling, MyD88-independent toll-like receptor signaling pathway, necroptotic process, necroptotic signaling pathway, negative regulation of apoptotic process, negative regulation of cardiac muscle cell proliferation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of I-kappaB kinase/NF-kappaB signaling, peptidyl-serine autophosphorylation, positive regulation of apoptotic process, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of hydrogen peroxide-induced cell death, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-8 production, positive regulation of JNK cascade, positive regulation of macrophage differentiation, positive regulation of necroptotic process, positive regulation of necrotic cell death, positive regulation of NF-kappaB transcription factor activity, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of programmed cell death, positive regulation of protein phosphorylation, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of tumor necrosis factor production, programmed necrotic cell death, protein autophosphorylation, protein deubiquitination, regulation of ATP:ADP antiporter activity, regulation of extrinsic apoptotic signaling pathway via death domain receptors, regulation of tumor necrosis factor-mediated signaling pathway, response to tumor necrosis factor, ripoptosome assembly, ripoptosome assembly involved in necroptotic process, T cell apoptotic process, toll-like receptor 3 signaling pathway, TRIF-dependent toll-like receptor signaling pathway, tumor necrosis factor-mediated signaling pathway, viral process
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GO - Molecular function (MF):
ATP binding, death domain binding, death receptor binding, identical protein binding, JUN kinase kinase kinase activity, protein-containing complex binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, ubiquitin protein ligase binding...
ATP binding, death domain binding, death receptor binding, identical protein binding, JUN kinase kinase kinase activity, protein-containing complex binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, ubiquitin protein ligase binding
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GO - Cellular component (CC):
cytosol, ripoptosome, endosome membrane, mitochondrion, death-inducing signaling complex, membrane raft, protein-containing complex, receptor complex...
cytosol, ripoptosome, endosome membrane, mitochondrion, death-inducing signaling complex, membrane raft, protein-containing complex, receptor complex
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receptor interacting serine/threonine kinase 1
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A-loop
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Kaplan plot for RIPK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc