CAMK2G
Entrez ID: 818
Full name: calcium/calmodulin dependent protein kinase II gamma
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK2
Chromosomal location: 10q22.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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CAMK2G
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch...
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
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GO - Biological processes (BP):
insulin secretion, interferon-gamma-mediated signaling pathway, regulation of calcium ion transport, regulation of cellular response to heat, regulation of neuron projection development, regulation of skeletal muscle adaptation...
insulin secretion, interferon-gamma-mediated signaling pathway, regulation of calcium ion transport, regulation of cellular response to heat, regulation of neuron projection development, regulation of skeletal muscle adaptation
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, protein homodimerization activity...
ATP binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, protein homodimerization activity
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GO - Cellular component (CC):
cytosol, sarcoplasmic reticulum membrane, nucleoplasm, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endocytic vesicle membrane, membrane, neuron projection...
cytosol, sarcoplasmic reticulum membrane, nucleoplasm, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endocytic vesicle membrane, membrane, neuron projection
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calcium/calmodulin dependent protein kinase II gamma
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Kaplan plot for CAMK2G in
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*NOTE: the Kaplan plots were collected from OncoLnc