CAMK2D
Entrez ID: 817
Full name: calcium/calmodulin dependent protein kinase II delta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK2
Chromosomal location: 4q26
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 47...49
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CAMK2D
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR...
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
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GO - Biological processes (BP):
cardiac muscle cell contraction, cellular response to calcium ion, endoplasmic reticulum calcium ion homeostasis, interferon-gamma-mediated signaling pathway, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity, peptidyl-ser...
cardiac muscle cell contraction, cellular response to calcium ion, endoplasmic reticulum calcium ion homeostasis, interferon-gamma-mediated signaling pathway, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cardiac muscle hypertrophy, protein autophosphorylation, protein phosphorylation, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of cardiac muscle cell action potential, regulation of cardiac muscle cell action potential involved in regulation of contraction, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cell communication by electrical coupling, regulation of cell communication by electrical coupling involved in cardiac conduction, regulation of cell growth, regulation of cellular localization, regulation of cellular response to heat, regulation of heart contraction, regulation of heart rate by cardiac conduction, regulation of histone deacetylase activity, regulation of membrane depolarization, regulation of relaxation of cardiac muscle, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of ryanodine-sensitive calcium-release channel activity, regulation of the force of heart contraction, regulation of transcription by RNA polymerase II, relaxation of cardiac muscle
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GO - Molecular function (MF):
ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, ion channel binding, protein homodimerization activity, protein serine/threonine kinase activity, sodium channel inhibitor activity, titin binding...
ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, ion channel binding, protein homodimerization activity, protein serine/threonine kinase activity, sodium channel inhibitor activity, titin binding
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GO - Cellular component (CC):
cytosol, sarcoplasmic reticulum membrane, nucleoplasm, nucleus, sarcolemma, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endocytic vesicle membrane, membrane, neuron projection...
cytosol, sarcoplasmic reticulum membrane, nucleoplasm, nucleus, sarcolemma, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endocytic vesicle membrane, membrane, neuron projection
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calcium/calmodulin dependent protein kinase II delta
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*NOTE: the Kaplan plots were collected from OncoLnc