DYRK1A
Entrez ID: 1859
Full name: dual specificity tyrosine phosphorylation regulated kinase 1A
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: DYRK: DYRK1
Chromosomal location: 21q22.13
Substructure location: Gatekeeper: 238 A-loop: 306...326 G-loop: 166...173 αC-helix: 194...212
Please click HERE
for better display.
DYRK1A
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate pre...
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
View more >>
GO - Biological processes (BP):
amyloid-beta formation, circadian rhythm, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of microtubule polymerization, negative regulation of mRNA splicing, via spliceosome, nervous system development, peptidyl-serine autophosphorylation, ...
amyloid-beta formation, circadian rhythm, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of microtubule polymerization, negative regulation of mRNA splicing, via spliceosome, nervous system development, peptidyl-serine autophosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of protein deacetylation, positive regulation of RNA splicing, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation, regulation of alternative mRNA splicing, via spliceosome, viral process
View more >>
GO - Molecular function (MF):
actin binding, ATP binding, cytoskeletal protein binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein self-association, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosin...
actin binding, ATP binding, cytoskeletal protein binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein self-association, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, tau protein binding, tau-protein kinase activity, transcription coactivator activity, tubulin binding
View more >>
GO - Cellular component (CC):
cytoskeleton, nuclear speck, nucleoplasm, nucleus, axon, cytoplasm, dendrite, ribonucleoprotein complex...
cytoskeleton, nuclear speck, nucleoplasm, nucleus, axon, cytoplasm, dendrite, ribonucleoprotein complex
View more >>
dual specificity tyrosine phosphorylation regulated kinase 1A
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DYRK1A in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc