BMPR2
Entrez ID: 659
Full name: bone morphogenetic protein receptor type 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR2
Chromosomal location: 2q33.1-q33.2
Substructure location: Gatekeeper: 279 A-loop: 350...360, 369...381 G-loop: 209...215 αC-helix: 234...236
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BMPR2
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less ef...
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
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GO - Biological processes (BP):
anterior/posterior pattern specification, aortic valve development, artery development, atrial septum morphogenesis, blood vessel development, blood vessel remodeling, BMP signaling pathway, brain development, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular r...
anterior/posterior pattern specification, aortic valve development, artery development, atrial septum morphogenesis, blood vessel development, blood vessel remodeling, BMP signaling pathway, brain development, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular response to starvation, chondrocyte development, endocardial cushion development, endochondral bone morphogenesis, endothelial cell apoptotic process, endothelial cell proliferation, limb development, lung alveolus development, lymphangiogenesis, lymphatic endothelial cell differentiation, maternal placenta development, mesoderm formation, mitral valve morphogenesis, negative regulation of cell growth, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of chondrocyte proliferation, negative regulation of DNA biosynthetic process, negative regulation of systemic arterial blood pressure, negative regulation of vasoconstriction, outflow tract morphogenesis, outflow tract septum morphogenesis, pharyngeal arch artery morphogenesis, positive regulation of axon extension involved in axon guidance, positive regulation of BMP signaling pathway, positive regulation of bone mineralization, positive regulation of cartilage development, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell migration, positive regulation of ossification, positive regulation of osteoblast differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of transcription by RNA polymerase II, protein phosphorylation, proteoglycan biosynthetic process, pulmonary valve development, regulation of cell population proliferation, regulation of lung blood pressure, retina vasculature development in camera-type eye, semi-lunar valve development, transcription by RNA polymerase II, transmembrane receptor protein serine/threonine kinase signaling pathway, tricuspid valve morphogenesis, vasculature development, venous blood vessel development, ventricular septum morphogenesis
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GO - Molecular function (MF):
activin receptor activity, type II, ATP binding, BMP binding, BMP receptor activity, cadherin binding, growth factor binding, metal ion binding, protein serine/threonine kinase activity, protein tyrosine kinase binding, transforming growth factor beta-activated receptor activity...
activin receptor activity, type II, ATP binding, BMP binding, BMP receptor activity, cadherin binding, growth factor binding, metal ion binding, protein serine/threonine kinase activity, protein tyrosine kinase binding, transforming growth factor beta-activated receptor activity
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GO - Cellular component (CC):
extracellular space, nucleoplasm, apical plasma membrane, basal plasma membrane, caveola, integral component of plasma membrane, plasma membrane, spanning component of plasma membrane, adherens junction, cell surface, cytoplasm, dendrite, neuronal cell body, postsynaptic density, receptor complex...
extracellular space, nucleoplasm, apical plasma membrane, basal plasma membrane, caveola, integral component of plasma membrane, plasma membrane, spanning component of plasma membrane, adherens junction, cell surface, cytoplasm, dendrite, neuronal cell body, postsynaptic density, receptor complex
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bone morphogenetic protein receptor type 2
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Kaplan plot for BMPR2 in
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*NOTE: the Kaplan plots were collected from OncoLnc