CAMK1
Entrez ID: 8536
Full name: calcium/calmodulin dependent protein kinase I
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK1
Chromosomal location: 3p25.3
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 66...70
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CAMK1
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes ...
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x2-[ST]-x3-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
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GO - Biological processes (BP):
cell cycle, negative regulation of protein binding, nucleocytoplasmic transport, positive regulation of dendritic spine development, positive regulation of muscle cell differentiation, positive regulation of neuron projection development, positive regulation of peptidyl-serine phosphorylation, posit...
cell cycle, negative regulation of protein binding, nucleocytoplasmic transport, positive regulation of dendritic spine development, positive regulation of muscle cell differentiation, positive regulation of neuron projection development, positive regulation of peptidyl-serine phosphorylation, positive regulation of protein acetylation, positive regulation of protein export from nucleus, positive regulation of protein serine/threonine kinase activity, positive regulation of synapse structural plasticity, positive regulation of syncytium formation by plasma membrane fusion, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of muscle cell differentiation, regulation of protein binding, regulation of protein localization, signal transduction
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GO - Molecular function (MF):
ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, protein serine/threonine kinase activity...
ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, glutamatergic synapse, postsynaptic density...
cytosol, nucleus, glutamatergic synapse, postsynaptic density
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calcium/calmodulin dependent protein kinase I
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Kaplan plot for CAMK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc