MELK
Entrez ID: 9833
Full name: maternal embryonic leucine zipper kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: MELK
Chromosomal location: 9p13.2
Substructure location: Gatekeeper: 86 A-loop: 149...160, 162...173 G-loop: [N/A] αC-helix: 44...47
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MELK
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating ...
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
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GO - Biological processes (BP):
apoptotic process, cell population proliferation, G2/M transition of mitotic cell cycle, hemopoiesis, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, neural precursor cell proliferation, positive regulation of apoptotic process, protein autop...
apoptotic process, cell population proliferation, G2/M transition of mitotic cell cycle, hemopoiesis, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, neural precursor cell proliferation, positive regulation of apoptotic process, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, calcium ion binding, lipid binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine kinase activity...
ATP binding, calcium ion binding, lipid binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, plasma membrane, cell cortex, cytoplasm, membrane...
nucleus, plasma membrane, cell cortex, cytoplasm, membrane
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maternal embryonic leucine zipper kinase
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Kaplan plot for MELK in
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*NOTE: the Kaplan plots were collected from OncoLnc