PDK1
Entrez ID: 5163
Full name: pyruvate dehydrogenase kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PDHK: PDHK
Chromosomal location: 2q31.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PDK1
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-...
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
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GO - Biological processes (BP):
cell population proliferation, glucose homeostasis, glucose metabolic process, hypoxia-inducible factor-1alpha signaling pathway, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of pyruvate dehydrogenase activity, regulation of acetyl-CoA biosynthetic proce...
cell population proliferation, glucose homeostasis, glucose metabolic process, hypoxia-inducible factor-1alpha signaling pathway, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of pyruvate dehydrogenase activity, regulation of acetyl-CoA biosynthetic process from pyruvate, regulation of glucose metabolic process
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity
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GO - Cellular component (CC):
mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion, nucleolus, nucleoplasm...
mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion, nucleolus, nucleoplasm
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pyruvate dehydrogenase kinase 1
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αC-helix
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Kaplan plot for PDK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc