PDK2
Entrez ID: 5164
Full name: pyruvate dehydrogenase kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PDHK: PDHK
Chromosomal location: 17q21.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PDK2
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, d...
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
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GO - Biological processes (BP):
cellular response to nutrient, cellular response to reactive oxygen species, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of pyruvate dehydrogenase activity, regulation of acetyl-C...
cellular response to nutrient, cellular response to reactive oxygen species, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of pyruvate dehydrogenase activity, regulation of acetyl-CoA biosynthetic process from pyruvate, regulation of calcium-mediated signaling, regulation of cellular ketone metabolic process, regulation of gluconeogenesis, regulation of glucose metabolic process, regulation of pH
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GO - Molecular function (MF):
ATP binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity...
ATP binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity
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GO - Cellular component (CC):
cytosol, mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion, nucleoplasm...
cytosol, mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion, nucleoplasm
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pyruvate dehydrogenase kinase 2
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Kaplan plot for PDK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc