PDK3
Entrez ID: 5165
Full name: pyruvate dehydrogenase kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PDHK: PDHK
Chromosomal location: Xp22.11
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PDK3
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a hig...
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
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GO - Biological processes (BP):
cellular response to fatty acid, cellular response to glucose stimulus, glucose homeostasis, glucose metabolic process, hypoxia-inducible factor-1alpha signaling pathway, negative regulation of pyruvate dehydrogenase activity, peptidyl-serine phosphorylation, peroxisome proliferator activated recept...
cellular response to fatty acid, cellular response to glucose stimulus, glucose homeostasis, glucose metabolic process, hypoxia-inducible factor-1alpha signaling pathway, negative regulation of pyruvate dehydrogenase activity, peptidyl-serine phosphorylation, peroxisome proliferator activated receptor signaling pathway, regulation of acetyl-CoA biosynthetic process from pyruvate, regulation of glucose metabolic process, regulation of reactive oxygen species metabolic process
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity
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GO - Cellular component (CC):
mitochondrial matrix, mitochondrion, nucleolus, cell...
mitochondrial matrix, mitochondrion, nucleolus, cell
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pyruvate dehydrogenase kinase 3
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αC-helix
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Kaplan plot for PDK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc