CDK10
Entrez ID: 8558
Full name: cyclin dependent kinase 10
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK10
Chromosomal location: 16q24.3
Substructure location: Gatekeeper: 117 A-loop: 180...191, 193...203 G-loop: [N/A] αC-helix: [N/A]
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CDK10
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. ...
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
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GO - Biological processes (BP):
cell projection organization, negative regulation of cell population proliferation, negative regulation of cilium assembly, peptidyl-threonine phosphorylation, positive regulation of MAPK cascade, protein phosphorylation, regulation of actin cytoskeleton organization, traversing start control point ...
cell projection organization, negative regulation of cell population proliferation, negative regulation of cilium assembly, peptidyl-threonine phosphorylation, positive regulation of MAPK cascade, protein phosphorylation, regulation of actin cytoskeleton organization, traversing start control point of mitotic cell cycle
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GO - Molecular function (MF):
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein serine/threonine kinase activity...
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
ciliary basal body, nucleus, cytoplasm...
ciliary basal body, nucleus, cytoplasm
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cyclin dependent kinase 10
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*NOTE: the Kaplan plots were collected from OncoLnc