RPS6KA2
Entrez ID: 6196
Full name: ribosomal protein S6 kinase A2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: RSK: RSKp90
Chromosomal location: 6q27
Substructure location: Gatekeeper: 486 A-loop: 201...212, 214...224, 553...576 G-loop: [N/A] αC-helix: [N/A]
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RPS6KA2
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor...
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
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GO - Biological processes (BP):
intracellular signal transduction, negative regulation of cell cycle, negative regulation of cell population proliferation, positive regulation of apoptotic process, protein phosphorylation, signal transduction...
intracellular signal transduction, negative regulation of cell cycle, negative regulation of cell population proliferation, positive regulation of apoptotic process, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity...
ATP binding, magnesium ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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ribosomal protein S6 kinase A2
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Kaplan plot for RPS6KA2 in
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*NOTE: the Kaplan plots were collected from OncoLnc