EPHA7
Entrez ID: 2045
Full name: EPH receptor A7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 6q16.1
Substructure location: Gatekeeper: 711 A-loop: 775...801 G-loop: 639...645 αC-helix: 673...686
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EPHA7
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pa...
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
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GO - Biological processes (BP):
apoptotic process, axon guidance, brain development, branching morphogenesis of a nerve, ephrin receptor signaling pathway, multicellular organism development, negative chemotaxis, negative regulation of collateral sprouting, negative regulation of synapse assembly, nephric duct morphogenesis, phosp...
apoptotic process, axon guidance, brain development, branching morphogenesis of a nerve, ephrin receptor signaling pathway, multicellular organism development, negative chemotaxis, negative regulation of collateral sprouting, negative regulation of synapse assembly, nephric duct morphogenesis, phosphorylation, positive regulation of kinase activity, positive regulation of neuron apoptotic process, positive regulation of protein phosphorylation, regulation of cell-cell adhesion, regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of ERK1 and ERK2 cascade, regulation of peptidyl-tyrosine phosphorylation, regulation of postsynapse organization, regulation of protein autophosphorylation, retinal ganglion cell axon guidance, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, axon guidance receptor activity, chemorepellent activity, ephrin receptor binding, GPI-linked ephrin receptor activity, protein tyrosine kinase activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, axon guidance receptor activity, chemorepellent activity, ephrin receptor binding, GPI-linked ephrin receptor activity, protein tyrosine kinase activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
integral component of plasma membrane, integral component of postsynaptic density membrane, plasma membrane, dendrite, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, neuromuscular junction, neuron projection, neuronal cell body, receptor complex, Schaffer collateral - CA1 synapse...
integral component of plasma membrane, integral component of postsynaptic density membrane, plasma membrane, dendrite, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, neuromuscular junction, neuron projection, neuronal cell body, receptor complex, Schaffer collateral - CA1 synapse
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EPH receptor A7
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Kaplan plot for EPHA7 in
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*NOTE: the Kaplan plots were collected from OncoLnc