GRK1
Entrez ID: 6011
Full name: G protein-coupled receptor kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: GRK: GRK
Chromosomal location: 13q34
Substructure location: Gatekeeper: 267 A-loop: 334...357 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
GRK1
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumin...
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
View more >>
GO - Biological processes (BP):
protein autophosphorylation, regulation of G protein-coupled receptor signaling pathway, regulation of rhodopsin mediated signaling pathway, rhodopsin mediated signaling pathway, visual perception...
protein autophosphorylation, regulation of G protein-coupled receptor signaling pathway, regulation of rhodopsin mediated signaling pathway, rhodopsin mediated signaling pathway, visual perception
View more >>
GO - Molecular function (MF):
ATP binding, G protein-coupled receptor kinase activity, protein kinase activity, rhodopsin kinase activity...
ATP binding, G protein-coupled receptor kinase activity, protein kinase activity, rhodopsin kinase activity
View more >>
GO - Cellular component (CC):
photoreceptor disc membrane...
photoreceptor disc membrane
View more >>
G protein-coupled receptor kinase 1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for GRK1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc